Myelofibrosis

You could experience a reduction in those symptoms within the first week or it might take some time. ## Hi Mark, Judging from the wording of your post, I couldn't exactly interpret whether you were replying to someone in particular or just stating some facts you found on the internet about "myelofibrosis fever (MF)"? In either case, what I can agree with is that the prognosis of MF is in fact different for every patient. One important thing to be aware of if you have Myelofibrosis, is that even if you don't experience any symptoms, a doctor could still find "signs" of it during a physical examination (i.e. an enlarged spleen or pale mucous membranes). So it would probably be best to have yourself checked out periodically until you know for certain that it's g...

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JIM HAS NOW BEEN ON RUXOLITINIB FOR 8 WEEKS AND FEELING AND LOOKING MUCH BETTER THAN BEFORE HE STARTED THE MEDICATION. PROBLEM IS HIS ANEMIA IS A PROBLEM, ONLY 7.7 AND TRANSUFISIONS ONCE A WEEK AND HIS PLATLET LEVEL IS WAY UP AT 1200. AFTER THE FIRST 4 WEEKS FELT SO MUCH BETTER, NOW NOT FEELING AS GOOD AS HE WAS. GOING TO THE SPECIALIST ON THURSDAY, MAYBE HIS DOSAGE NEEDS ADJUSTING. ANYONE ELSE HAD THIS PROBLEM? PLEASE SHARE IF YOU HAVE. HE IS TAKING 2OMGS, TWICE A DAY. ## What was his levels before starting? Jim may want to try 15mg twice a day and see if his counts bounce back. ## It would appear that you two have found each other on both active discussions on this medication: This is a very new treatment, so the available information is limited: Carol, how is your husband doing on it...

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I have stage 3 advanced Myelofibrosis and have been taking Ruxolitinib (Jakafi) for almost 9 weeks. I have had almost 50% reduction in my spleen size and my bloods have returned to close to normal. I am seeing Dr Patrick Tan at Mount Elizabeth Hospital in Singapore and I am paying for the treatment myself as I do not have medical insurance. A bottle of 60 x 5mg pills costs me Singapore$3,450.00 and I get a VAT refund when I leave Singapore if I have not opened the drug before I depart. I am taking 4 x 5mg twice a day so it is quite expensive but the results have been terrific. I can highly recommend yhr hodpital and specialist in Singapore. ## Dear Steve, My mom needs Jakafi too, where I can find it in Singapore at $3,450? Thank you so much, I'm from Chile ## Dear all. My name is St...

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I'm 3 yrs into Post-Essential Thrombocythemia Myelofibrosis, and I'm wondering if anyone out there has taken Ruxolitinib w/what I've got and had any success? ## There are support groups you could check with: Quick Topic...Myelofibrosis Facebook...Myelofibrosis Also several people on tweeter I've found. I have Myelofibrosis, but have not been on Ruxo ## Has anyone tried adopting a low fat high carb raw vegan (primarily fruitarian) lifestyle in addition to juicing leafy greens to see if it has any positive impact on Myelofibrosis? I thought I'd mention this because I've heard of individuals experiencing all different types of miracles over the coarse of a few months to a few years, in relation to getting rid of all types of cancers and other ailments that are other...

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I have been on clinical trial 2 yrs for myelofibrosis and wanted to know if anyone's health insurance is paying for the drug in case the clinical trial ends? What is the approximate cost per month? I have seen it is around $7000 month on another website. Any info would be appreciated. Thank you. ## That is about the same estimated price that I am seeing listed everywhere, which is pretty normal for these types of medications, especially being this new. I've no information on insurances covering it, though. That would depend on the insurance and if it actually gets approval. Does anyone else have more information on this? ## Thanks for the reply. Its now approved for sale in the U.S. I am live in Ca. I use wall greens drug store. I checked with them its $4.400.00 without insuranc...

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Pacritinib

Pacritinib, sold under the brand name Vonjo, is an anti-cancer medication used to treat myelofibrosis.[1][2] It is a macrocyclic Janus kinase inhibitor. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3 (FLT3). Common side effects include diarrhea, low platelet counts, nausea, anemia, and swelling in legs.[2] Contents 1 Medical uses 2 History 3 Society and culture 3.1 Names 4 References 5 External links Medical us...

Drug Index

Pacritinib, sold under the brand name Vonjo, is an anti-cancer medication used to treat myelofibrosis.[1][2] It is a macrocyclic Janus kinase inhibitor. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3 (FLT3). Common side effects include diarrhea, low platelet counts, nausea, anemia, and swelling in legs.[2] Contents 1 Medical uses 2 History 3 Society and culture 3.1 Names 4 References 5 External links Medical us...

Ruxolitinib

Ruxolitinib, sold under the brand names Jakafi and Jakavi, is a medication for the treatment of intermediate or high-risk myelofibrosis,[1] a type of myeloproliferative disorder that affects the bone marrow;[5][6] polycythemia vera (PCV), when there has been an inadequate response to or intolerance of hydroxyurea;[1][7] and steroid-refractory acute graft-versus-host disease.[1] It was developed and...

Ruxolitinib Phosphate

Ruxolitinib, sold under the brand names Jakafi and Jakavi, is a medication for the treatment of intermediate or high-risk myelofibrosis,[1] a type of myeloproliferative disorder that affects the bone marrow;[5][6] polycythemia vera (PCV), when there has been an inadequate response to or intolerance of hydroxyurea;[1][7] and steroid-refractory acute graft-versus-host disease.[1] It was developed and...

Drug Index

Ruxolitinib, sold under the brand names Jakafi and Jakavi, is a medication for the treatment of intermediate or high-risk myelofibrosis,[1] a type of myeloproliferative disorder that affects the bone marrow;[5][6] polycythemia vera (PCV), when there has been an inadequate response to or intolerance of hydroxyurea;[1][7] and steroid-refractory acute graft-versus-host disease.[1] It was developed and...

Fedratinib Hydrochloride

Fedratinib, sold under the brand name Inrebic, is an anti-cancer medication used to treat myeloproliferative diseases including myelofibrosis.[3] It is used in the form of fedratinib hydrochloride capsules that are taken by mouth. It is a semi-selective inhibitor of Janus kinase 2 (JAK-2).[3][4] It was approved by the FDA on 16 August 2019.[3] Myelofibrosis is a myeloid cancer associated with anemia, splenomegaly, and constitutio...

Drug Index

Fedratinib, sold under the brand name Inrebic, is an anti-cancer medication used to treat myeloproliferative diseases including myelofibrosis.[3] It is used in the form of fedratinib hydrochloride capsules that are taken by mouth. It is a semi-selective inhibitor of Janus kinase 2 (JAK-2).[3][4] It was approved by the FDA on 16 August 2019.[3] Myelofibrosis is a myeloid cancer associated with anemia, splenomegaly, and constitutio...

Does anybody have an idea how can Jakafi be bought outside the united states? what is the price? ## I got Jakafi through my doctor for the treatment of myelofibrosis. We had to fill out an application for it from the pharmacuetical company, "Incyte". It has not been made available to local pharmacies, only through the way I just described. ## That is correct, it is currently still in the investigational stage, so it hasn't actually been approved and isn't publicly available anywhere, which also means that there is no price to give anyone. You can learn more about it here: Are there any other questions or comments? ## I am in Indonesia at the moment, and my dad's doctor recommended him to try JAKAFI. But it is only still available in US. My dad is feeling horrible at ...

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I have been takining this drug Jakavi for 18 months for the treatment of Myleofibrosis. My spleen has reduced in size, my blood levels are much closer to normal range except for the Haemoglobin which is low. My concern is that since the commencement of the course of the drug my PSA level has increased drastically. Has anyone else experienced this? ## Further: my most recent PSA reading is 27.5 and have had a Biopsy of Prostate which is negative of cancer. Could drug Jakavi or Ruxolitnib or the Myelofibrosis be influencing the PSA reading? ## Am on Jakafi 20mg twice a day for last 2 years and recent psa increased from 5 to 16 over that time. Am going to dr tomorrow to check about biopsy so will try to match my info with yours, but from my readings it is a possible side effect.

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I am interested in how soon after starting with ruxolitinib one can feel improvement of symptoms, specifically, fever/chills/night sweats.