Metformin 1000mg Leg

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I have been taking normal metformin (1000mg per day) since April 2014. It had a strong GI effect on me (10 bathroom trips between bathroom and lunchtime), and truthfully, there were times I couldn't take it at all if I wanted to be able to leave my home due to those side effects. My doctor felt that although metformin commonly has gastro side effects, mine were on the extreme side. He switched me to 1000mg of metformin ER to see if that would help things. It did, however two days after taking the ER, my left leg broke out in hives. Only the left leg, on the front shin area. My doctor switched me back to the regular metformin (but only 500mg at night) to see if it was maybe an additive in the ER version that I might be allergic to. However, neither of us could explain why an allergy ...

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