Linzess Stopped Working

I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...

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I started taking the low dose now I take too of them a day...only had one bowel movement when I started ...don't know what to do not #help ## Hello, Terri! How are you? Are you making sure to take it in the morning, with a full 8 ounce glass of water, at least a half hour, before eating or drinking anything else? It seems that some people weren't told that by their doctor or pharmacist. The FDA lists its typical side effects as possibly including nausea, bloating and diarrhea. ## Exactly right. That is how my doctor instructed me and it works, usually within an hour. ## Hi Terri, Linzess stopped working for me as well after about a year. One thing that did help me while on it was after taking it in the morning with a big glass of water, I would waite about 15 mins and drink a 6 ...

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I have been on Linzess 145 mg for a month. it worked great the first 2 weeks and now it just stopped. I don't know if my body got use to it already or what could cause it. ## Hello, Marci! How are you? I'm very sorry about the problem that you're having. Actually, that has been a very common complaint from people that have tried it. However, there is a higher dosage that you can try, so you may want to speak to your doctor about prescribing it. Typical side effects to this medication may include stomach pain, nausea, gas or bloating. Have you been taking it on an empty stomach? ## Yes I've been taking it on an empty stomach & I've even doubled the dosage & it doesn't work. I finally resorted to taking Milk of magnesia nstead because I was so miserable ## ...

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I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of miralax daily (which stopped working), amitiza (never worked) and now Linzess. The very first day it caused severe pain and I had pretty severe diarrhea. The next few days & nights I had severe abdominal pain, but now just cramping and lots of bloating. I have not had ANY movements at all since the diarhea on day 1. Is this normal? ## I hope your seeing a gastroenterologist and if so CALL the doctor. ## Hi GPcrusader, Sorry to hear about your situation. From what I've read on other related threads, the time it takes for Linzess to work actually varies greatly for each and every individual. However, I do agree with Amber in that it might be a good idea to touch base w...

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I have suffered constipation for years- sometimes no BM for weeks. Eventually- I just stopped all BM completely. I resorted to bisacodyl once per week. Eventually, I had to take 4 at a time- until that stopped working. Scheduled colonoscopy but the prep didn't work. Second prep did only because I mixed it with large amounts of bisacodyl. Results showed nothing. Doctor gave me linzess. 145 mg didn't work. 290 mg also didn't work. So, again, I took lots of bisacodyl. After that, I started the linzess again- after the clean out, I am now having BM every other day. Very loose but after the BM it's not like I'm running to the bathroom all day. I suspect I will have to periodically take the bisacodyl to keep things moving- but maybe only once every couple weeks instead of ...

I started on the lower dosage 2 weeks ago, and I didn't go the whole week. Doctor bumped me up to the 290 dosage and have only had 2 very small bms a little loose. That is it! I keep reading about how everyone is getting diahhrea several times a day. I take it every morning 30 minutes to one hour before I eat or take any other medicine. It's like everything has stopped working. Even hard to pass gas. My stomach is distended and I have rumbling, but nothing coming out. Do I just continue to take and wait for it to work? So far, not very impressed with Linzess! ## I'm sorry about the problem you're having. Are you making sure to take it a full glass of water? Unfortunately, this medication doesn't work for everyone that tries it. The FDA lists its typical side effects ...

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After taking linzess for 8 months I gained 20 pounds and developed every symptom for hypothyroidism again. For the past 12 years I have been on synthroid 75. I have not had any hypothyroid symptoms once I began taking synthroid until taking the linzess medication. I stopped taking linzess and hoping it will exit my body quickly so my synthroid meds will begin working again. Why don't doctors tell you it prevents your thyroid meds from working? Why don't they tell you it will make you gain weight? I just hope I can get my thyroid and my weight under control again. ## A follow up on my hypothyroidism symptoms that was caused by Linzess: dr ran a TSH, T4, and a T3 blood test and the results showed I was on the low end but still within the acceptable range of the T3, the T4 and TSH ...

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I have multiple sclerosis and my doctor gave me movantik I took it for 3 days and it worked but I went into terrible withdrawal. It worked then it stopped working. another person told me to take it with linzess and I did not go. two nights ago I took miralax I went to the bathroom yesterday a few times however today I am so bloated i am afraid. please help ## Hello, Rifka! How are you? Linzess is known to cause bloating as a side effect as reported by the FDA, the Miralax can also cause it. It can also be a symptom of constipation, thus you've got several good reasons for why you may be bloated. However, if you're concerned, you should consult your doctor, they may be able to help you alleviate it and perhaps give you a more accurate idea as to its cause. Are you on any other me...

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