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Drug Index

Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor.[1] It is a drug that may improve the prognosis in patients with congestive heart failure.[2] Amrinone has been shown to increase the contractions initiated in the heart by high-gain calcium induced calcium release (CICR).[3] The positive inotropic effect of amrinone is mediated by the selective enhancement of high-gain CICR, which contributes to...

Droperidol

Droperidol /droprIdl/ (Inapsine, Droleptan, Dridol, Xomolix, Innovar [combination with fentanyl]) is an antidopaminergic drug used as an antiemetic (that is, to prevent or treat nausea) and as an antipsychotic. Droperidol is also often used as a sedative in intensive-care treatment. Contents 1 History 2 Medical use 3 Black box warning 4 Side effects 5 Chemistry 6 References 7 Further reading History Discovered at Janssen Pharmaceutica in 1961, droperidol is a butyrophenone which acts a...

Drug Index

Prenatal vitamins, also known as prenatal supplements, are vitamin and mineral supplements intended to be taken before and during pregnancy and during postnatal lactation. Although not intended to replace a healthy diet, prenatal vitamins provide women of childbearing age with nutrients recognized by the various health organizations including the American Dietetic Association[citation needed] as helpful for a healthy pregnancy outcome. It may be appropriate to start taking pr...

Drug Index

Prenatal vitamins, also known as prenatal supplements, are vitamin and mineral supplements intended to be taken before and during pregnancy and during postnatal lactation. Although not intended to replace a healthy diet, prenatal vitamins provide women of childbearing age with nutrients recognized by the various health organizations including the American Dietetic Association[citation needed] as helpful for a healthy pregnancy outcome. It may be appropriate to start taking pr...

Levodopa

l-DOPA, also known as levodopa and l-3,4-dihydroxyphenylalanine, is an amino acid that is made and used as part of the normal biology of some plants and animals, including humans. Humans, as well as a portion of the other animals that utilize l-DOPA, make it via biosynthesis from the amino acid l-tyrosine. l-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. Furthermore, l-DOPA ...

Norethindrone

Norethisterone, also known as norethindrone and sold under many brand names, is a progestin medication used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.[3][5] The medication is available in both low-dose and high-dose formulations and both alone and in combination with an estrogen.[5][6] It is used by mouth or, as norethisterone enanthate, by injection into muscle.[...

Telaprevir

Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors.[3] Specifically, telaprevir inhibits the hepatitis C viral enzyme NS3/4A serine protease.[4] Telaprevir is only indicated for use against hepatitis C genotype 1 viral infections and has not been...

Drug Index

Inclisiran, sold under the brand name Leqvio, is a medication for the treatment of people with atherosclerotic cardiovascular disease (ASCVD), ASCVD risk equivalents and heterozygous familial hypercholesterolemia (HeFH). It is a small interfering RNA that inhibits translation of the protein PCSK9.[5][6][7][2] Inclisiran was approved for use in the European Union in December 2020.[4] In August 2021, it received NIC...

Drug Index

Botulinum toxin (BoNT) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species.[1] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis.[2] The toxin causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes. The seven main types of botulinum toxin are named types A to G (A, B, C1, C2, D, E, F and ...

Mecasermin Recombinant

Mecasermin (INN) (brand name Increlex), also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity).[1][2][3] Mecasermin has a biological half-life...

Umeclidinium Bromide

Umeclidinium bromide (trade name Incruse Ellipta) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).[1] It is also approved for this indication in combination with vilanterol (as umeclidinium bromide/vilanterol)[2][3] and also as a triple-therapy combination as fluticasone furoate/umeclidinium bromide/vilanterol.[4] It is on the World Health Organization...

Drug Index

Indacaterol is an ultra-long-acting beta-adrenoceptor agonist[5] developed by Novartis. It needs to be taken only once a day,[6] unlike the related drugs formoterol and salmeterol. It is licensed only for the treatment of chronic obstructive pulmonary disease (COPD) (long-term data in patients with asthma are thus far lacking). It is delivered as an aerosol formulation through a dry powder inhaler. Medical uses A Cochrane review found benefit in lung functi...

Drug Index

Indacaterol is an ultra-long-acting beta-adrenoceptor agonist[5] developed by Novartis. It needs to be taken only once a day,[6] unlike the related drugs formoterol and salmeterol. It is licensed only for the treatment of chronic obstructive pulmonary disease (COPD) (long-term data in patients with asthma are thus far lacking). It is delivered as an aerosol formulation through a dry powder inhaler. Medical uses A Cochrane review found benefit in lung functi...

Drug Index

Indapamide is a thiazide-like diuretic[2] drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events.[3] Both thiazide di...

Propranolol

Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker class.[1] It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors,[1][2][3] as well to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks.[1] It can...

Propranolol

Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker class.[1] It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors,[1][2][3] as well to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks.[1] It can...

Propranolol

Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker class.[1] It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors,[1][2][3] as well to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks.[1] It can...

Hydrochlorothiazide, HCTZ + Propranolol

Hydrochlorothiazide (HCTZ or HCT) is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.[3] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine.[3] Hydrochlorothiazide is less effective than chlortalidone for prevention of heart attack or stroke.[4] [3][5] HC...

Hydrochlorothiazide, HCTZ + Propranolol

Hydrochlorothiazide (HCTZ or HCT) is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.[3] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine.[3] Hydrochlorothiazide is less effective than chlortalidone for prevention of heart attack or stroke.[4] [3][5] HC...