093 Par

Paraldehyde

Paraldehyde is the cyclic trimer of acetaldehyde molecules.[2] Formally, it is a derivative of 1,3,5-trioxane, with a methyl group substituted for a hydrogen atom at each carbon. The corresponding tetramer is metaldehyde. A colourless liquid, it is sparingly soluble in water and highly soluble in ethanol. Paraldehyde slowly oxidizes in air, turning brown and producing an odour of acetic acid. It quickly reacts with most plastics and rubber. Paraldehyde was first observed in 18...

Rabeprazole

Rabeprazole, sold under the brand name Aciphex, among others, is a medication that decreases stomach acid.[6] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and excess stomach acid production such as in Zollinger–Ellison syndrome.[6] It may also be used in combination with other medications to treat Helicobacter pylori.[7] Effectiveness is similar to other proton pump inhibitors (PPIs).[8] It is ...

Buspirone

Buspirone, sold under the brand name Buspar, among others, is a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder.[9][10] Benefits support its short-term use.[11] It is taken by mouth, and it may take up to four weeks to have an effect.[9][10] Common side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating.[9]&#91...

Carbidopa + Levodopa

Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa.[1] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse.[1] It is taken by mouth.[1] It can take two to three weeks of treatment before benefits are seen.[2] Each dose then begins working in about ten minutes to two hours w...

Hydroxyamphetamine + Tropicamide

Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye.[3] Specifically it is used to help examine the back of the eye.[4] It is applied as eye drops.[3] Effects occur within 40 minutes and last for up to a day.[3] Common side effects include blurry vision, increased intraocular pressure, and sensitivity to light.[3] Another rare...

Tranylcypromine

Tranylcypromine (sold under the trade name Parnate among others)[1] is a monoamine oxidase inhibitor (MAOI); more specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO).[2][5] It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. Tranylcypromine is a propylamine formed from the cyclization of amphetamine's side chain...

Parathyroid Hormone

Recombinant human parathyroid hormone, sold under the brand names Preotact and Natpara, is an artificially manufactured form of the parathyroid hormone used to treat hypoparathyroidism.[1][2][4][5] Recombinant human parathyroid hormone is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures.[3] A significant reduction in the incidence of vertebral fractures has been ...

Selegiline

Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder.[1] It is provided in the form of a capsule or tablet taken by mouth for Parkinson's disease and as a patch applied to skin for depression. Selegiline acts as a monoamine oxidase inhibitor, and increases levels of monoamine neurotransmitters in the brain. At typical clinical dose...

Bromocriptine

Bromocriptine, originally marketed as Parlodel and subsequently under many brand names,[1] is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes. It was patented in 1968 and approved for medical use in 1975.[2] Contents 1 Medical uses 2 Side effects 3 Pharmacology 3.1 Pharmacodynamics 4 Chemistry 5 Histor...

Etelcalcetide

Etelcalcetide (formerly velcalcetide, trade name Parsabiv) is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. It is administered intravenously at the end of each dialysis session.[1][2] Etelcalcetide functions by binding to and activating the calcium-sensing receptor in the parathyroid gland.[1] Parsabiv is currently owned by Amgen and Ono Pharmaceuticals in Japan.[3]&am...

Olaparib

Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers.[6] In December 2014, olaparib was approved for use as a single agent by the European Medicines Agenc...

Drug Index

Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers.[6] In December 2014, olaparib was approved for use as a single agent by the European Medicines Agenc...

Cinacalcet

Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat secondary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism.[4][5][6] The most common side effects include nausea (feeling sick) and vomiting.[6] Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various...

Drug Index

Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved through much of Europe for short term perioperative pain control. It was patented in 1996 and approved for medical use in 2002.[1] Contents 1 Approval 2 See also 3 References 4 Further reading Approval In 2005, the U.S. Food and Drug Administration (FDA) issued a letter of non-appro...

Drug Index

Paregoric, or camphorated tincture of opium, also known as tinctura opii camphorata, is a traditional patent medicine known for its antidiarrheal, antitussive, and analgesic properties. According to Goodman and Gilman's 1965 edition, "Paregoric is a 4% opium tincture in which there is also benzoic acid, camphor, and anise oil. ... Paregoric by tradition is used especially for children."[1] The term "paregoric" has also been used for boiled sweets which contained the substance,...

Drug Index

.mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1} Aspartame[1] Names Pronunciation /æsprtem/ or /sprtem/ IUPAC name Methyl L-α-aspartyl-L-phenylalaninate Other names N-(L-α-Aspartyl)-L-phenylalanine,1-methyl ester Identifiers CAS Number 22839-47-0Y 3D model (JSmol) Interactive image ChEBI CHEBI:2877Y ChEMBL Ch...

Drug Index

Ardeparin (trade name Normiflo) is an anticoagulant. It was used for the prevention of deep vein thrombosis,[2] but was withdrawn from the US market in 2000.[3] References .mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}....

Drug Index

Niraparib, sold under the brand name Zejula, is an anti-cancer medication used for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer.[2][3][4] It is taken by mouth.[2][3] It is a PARP inhibitor. The most common side effects include nausea (feeling sick), thrombocytopenia (low blood platelet counts), tiredness and weakness, anemia (low red blood cell counts), constipation, vomiting, ...

Drug Index

Rucaparib, sold under the brand name Rubraca, is a PARP inhibitor used as an anti-cancer agent. Rucaparib is a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It is approved in the United States and in Europe as third line treatment in BRCA-mutated ovarian cancer.[3][4][5] It can be taken orally in tablet form.[2][6] The most common side effects include ti...