Active Ingredient(s): Denosumab
FDA Approved: * June 1, 2010
Pharm Company: * AMGEN
Category: Osteoporosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Prolia Overview

Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody[1] for the treatment of osteoporosis,[1] treatment-induced bone loss, metastases to bone,[1] and giant cell tumor of bone.[2] Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.[3] Denosumab is a RANKL inhibitor,[1] which works by preventing the development of osteoclasts which are cells that break down bone. It was developed by ...

Read more Prolia Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Prolia Forums: RSS Feed

Prolia side effects
2133 Replies RSS
Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab. I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia. Read more: Is there anyone else with experience using this? ## How are you doing now? Still now side effects? Please let us know ## I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terribl...
Updated 6 minutes ago.
Prolia side effects ongoing
154 Replies RSS
I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dry cough, near migraine type headaches, very severe weakness, trouble walking, constipation, had to have dental work that I usually have great teeth, some trouble sleeping. My rheumatologist did nothing to try to help me with the symptoms but my primary doctor gave me medication that help with the stomach pains, take Excedrin for Migraines and enteric aspirin for back and body, and other meds to try and find some comfort. I'm somewhat better than the few weeks after the infusion but still have a lot of problems. Hopefully this doesn't last for 6 months. ## Hello, Shirl! How are you? I'm so sorry about what you're going through. Everything you've list...
Updated 2 hours ago.
Prolia Nightmare!!!
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Had third Prolia shot 6 weeks ago and my life has changed dramatically. Nasea, headaches, numbness, tingling, weakness, back pain... I was very active and now am barely able to get out of bed! Four doctor visits, all kinds of tests, one ER visit and tests all normal. I am not crazy - it is the Prolia!!!! Don't do it. There are other more natural options to help with bone density. I regret getting this shot. By the way, first two shots had no significant side effects but the third one was debilitating!!!!
Updated 3 days ago.
Prolia & Hair Loss
171 Replies RSS
I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractures on my feet and have also taken fosamax. My current problem is hair loss & I wondered if anyone else was having that problem? ## Hello, Gracie! How are you? No, this isn't listed from what I can find, but I'll check a couple more sources to be sure and post back. Are you on any other medications? How old are you? ## I'm 57. On no other meds except evista and a pill for reflux. A friend sent me a website that stated that there was a study with some hair loss ## Yes, after my second shot of Prolea, I had two UTIs, fatigue, huge bumps under the skin on my face and all over my scalp, an array of unexplained symptoms like peripheral neuropathy (not diabeti...
Updated 4 days ago.
Prolia side effects Skin rash
20 Replies RSS
I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone else? ## Hello, Willy! How are you? That can be a side effect of Prolia, as listed by the FDA. You may also experience nausea, hypocalcemia, asthenia and fatigue. However, since it is itchy, you should have it checked out, because it could be an allergic reaction that requires medical treatment. Is there anything else I can help with? ## Willy, please look under Prolia side effects on this site. We have almost 900 people writing and talking about Prolia. You sort of worded your question wrong to land on the mega load of Prolia problems. Yes, it's from Prolia and requires medical attention. You will probably have to take written confirmation to make any MD believe yo...
Updated 6 days ago.
Side Effects Following Prolia Injection
70 Replies RSS
I am 60 yrs old and suffer from osteoarthritis, osteoporosis, and myofascial pain syndrome. After discussing with my endocrinologist, I received my first injection of Prolia two days ago. Had diarrhea approximately 12 hrs later in the middle of the night. Awoke the next day with headache over entire head and face. That evening (12:30 am) I vomited approximately 10 times in succession. Awoke 5 hrs later with terrible pain and tightness from the top of my head down my neck, shoulders, and upper back. I am frightened to see where the pain will travel next, especially after reading the posts on this forum. Is there a drug out there to counteract the Prolia. I will definitely not be getting another shot in 6 mos. My doctor told me that the main side effect of this drug is worsening of skin c...
Updated 11 days ago.
Discontinuing Prolia
4 Replies RSS
I started having prolia inj's. nearly 3 years ago. Shortly after the first one I found out about a study being done in South East Queensland, where I live, using carefully monitored weight training exercises to increase bone density. I started attending classes immediately. After 8 months, my second bone density scan showed that I had increased the density in my hip by 10% and in my spine by 6%. Other scans I have had since then have showed further improvement. I have read more about prolia since then and would very much like to discontinue it. I am hoping for some information on the effects of discontinuing prolia after 6 injections. I have heard that stopping the inj's. will result in a reduction of bone density once again. But, as I am also doing the weight bearing exercises ...
Updated 12 days ago.
How long on Prolia therapy for -2.6 bone loss?
1 Reply RSS
My bone density loss was -2.6 on December 2015, but after my third shot, my bone scan came back as -2.0 and I am going for a 4th shot this month. Can you tell me how many more shots I can go for, in order to become normal? I know my doctor might not be able to tell me how long. Please give me advice. Thank you! ## It sounds like your bone density loss has improved since the third shot. Do you find that to be the case as well based on how you feel? Have you gotten your 4th shot yet? And have any bone density results came back after the 4th shot to help determine your progress? In regards to how many shots one may need in order for bone density to become normal, my conclusion based on other Prolia discussion threads here, is that there's no way to know for certain because we all respo...
Updated 13 days ago.
teeth problems after taking prolia
21 Replies RSS
I took Prolia two months ago. I am developing loose teeth and sore spots on my gums. Have others experienced similar problems after taking Prolia? I go to the dentist regularly and have had no dental problems for several years. ## Hello, Dorrie! How are you? You should see your dentist to have this checked out. In certain rare cases, Prolia can cause osteonecrosis of the jaw, it's unlikely, but it would be best to have it checked out, to be sure. Other side effects, as listed by the FDA, may possibly include headache, vertigo, sciatica, anemia and rash. Is there anything else I can help with? ## I'm going to my Dentist for an X-ray of jaw bone tomorrow. Just started hurting this weekend which is Memorial Day weekend. So far, I have had every side effect that Prolia offers and my...
Updated 20 days ago.
Prolia issues and side effects
38 Replies RSS
I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered horrible side effects such as terrible constipation, leg and foot cramps, skin rashes, stomach pain,etc. I also found out that Prolia works by stopping the body's own bone production, causing old bone to become denser. This results in probable fractures due to old brittle bones, Prolia also causes low calcium levels in the blood, a weird side effect seeing it is supposed?to strengthen boned! ## I am sorry for your pain and suffering, I am on the "high risk list" for fractures, so having a product that has rebuilt bone mass in MY body is a blessing. No, I don't like the side effects, but I don't want to be in a wheel chair either.. Good Luck To You and...
Updated 27 days ago.

Possible Dosages for this and Related Drugs:

  • Injection: 60mg/ml, 70mg/ml
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Prolia: (1 result)

Sorted by National Drug Code
  • 55513-710 Prolia 60 mg/ml Subcutaneous Injection by Amgen Inc

Other drugs which contain Denosumab or a similar ingredient: (1 result)

Possibly related Prolia Topics:

Prolia side effects Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to... 2133 replies
Prolia & Hair Loss I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractur... 171 replies
Prolia side effects ongoing I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr... 154 replies
Prolia issues and side effects I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho... 38 replies
Prolia side effects Skin rash I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e... 20 replies
Prolia Injection Side Effects Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke... 13 replies
Prolia - Abundance Of Cavities From The Shot after my last dental hygiene appt. my dentist came in and stated the nurse who cleaned my teeth saw many cavities. they ... 10 replies
Prolia, strange side effects? I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t... 8 replies
Prolia and Leg Tremors I had a Prolia shot two weeks ago and am experiencing shaking and leg tremors. Are there others who have had this reacti... 8 replies
Prolia Jaw and gum pain, neck, shoulder arms and hip and thigh pain and tremors I took my first injection of Prolia mid April, I have gone to my dentist, he suggested a night guard. My rhuematologist ... 7 replies

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