Oxytrex

Oxytrex is an investigational drug currently in clinical trials. It combines the well known opioid agonist oxycodone in the treatment of pain with an ultra-low dose of naltrexone, an opioid antagonist. Naltrexone can have markedly different pharmacokinetics at ultra-low doses which may include, the attenuation of a pre-established opioid tolerance, the prevention of tolerance from the oxycodone in the formulation, and the possible amplification of oxycodone. It is being developed by Pain Ther... [wikipedia]