Category: Asthma

Mepolizumab Overview

Mepolizumab (trade name Nucala) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5). Mepolizumab has been investigated or is under investigation for the treatment of severe eosinophilic asthma, atopic dermatitis, hypereosinophilic syndrome (HES), eosinophilic esophagitis (EoE), nasal polyposis, eosinophilic granulomatosis with polyangiitis (EGPA) and chronic obstructive pulmonary disease (COPD). Phase III clinical trials in severe eosinophilic asthma were completed in 2014...

Read more Mepolizumab Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Mepolizumab Forums: RSS Feed

can mepolizumab be a cause for hypercalcemia?
1 Reply RSS
I have a patient on a trial with it, and now she has hypercalcemia. Could this be due to the med or do I have to investigate other causes. I cannot tell her or her specialist, otherwise I risk wrecking the double blinding. But doing nothing may delay diagnosis of something ominous. any advice? ## I'm sorry, but I haven't been able to find this as a side effect by either the FDA, or the manufacturer. The typical ones are listed as possibly including headache, back ache, and fatigue. Is the patient on any other medications?
Updated 1 month ago.
Hypereosinophilic syndrome treatment
3 Replies RSS
I have had HES for 12 years and want to trial Mepolizumab. My specialist has been unable to get me on a trial. What avenues do I have? ## It is really entirely up to the criteria set by the testing agencies and manufacturer, if they don't think you fit the patient profile, then they have the right to refuse you from their clinical trials and, unfortunately, you have no recourse in most countries. It's not the same as if someone were denying you a treatment options that has actually been proven to be life-sustaining. What reason did they give for not letting you into the trials? ## Thanks for your reply Verwon. In a nutshell, I didn't qualify for the trial because my death is not imminent. I have some control using hydroxyurea although the side effects depress all blood cell ...
Updated 11 months ago.

Possible Dosages for this and Related Drugs:

  • Injection: 100mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Mepolizumab: (1 result)

Sorted by National Drug Code
  • 0173-0881 Nucala 100 mg/ml Subcutaneous Injection, Powder, for Solution by Glaxosmithkline LLC

Other drugs which contain Mepolizumab or a similar ingredient: (1 result)

Possibly related Mepolizumab Topics:

can mepolizumab be a cause for hypercalcemia? I have a patient on a trial with it, and now she has hypercalcemia. Could this be due to the med or do I have to investi... 1 reply