Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Contrave Overview

Bupropion/naltrexone is a combination drug treatment for obesity.[1][2] It combines bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination is expected to have a synergistic effect.[3] In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave.[1] The combination was subsequently approved in the European Union in the spring of 2015, where it...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Contrave Forums: RSS Feed

Contrave: Dose time/Stomach ache
2 Replies RSS
I've been taking contrave for 3 weeks now and certainly have a decreased appetite. I'm having issues with constipation and a stomach ache in the middle of the night tho. What time is the second dose recommended? Perhaps evening rather than close to bedtime? I also get very tired after lunch and am wondering if changing my diet would help? Any suggestions? Finally, I used to have a few glasses of wine on the weekends and have a cigarette or two (yes I'm one of those smokers). However, I've lost both a taste for wine and definitely smoking since the first week. That can only be a good thing. Please share your thoughts. ## The listed FDA directions only say it should be taken in the evening, so I think adjusting it should be fine, unless your doctor has told you not to do s...
Updated 5 minutes ago.
Contrave Evening Dose
6 Replies RSS
I'm starting my 2nd week on Contrave tomorrow and the prescription says to take 1 in the morning and one in the evening. If I take the morning dose around 7 a.m., what time should I take the evening dose? I haven't been able to find any information on how far apart the doses should be taken. Thanks. ## Hello, Bobbye! How are you? It's usually taken at meal times, so with breakfast and dinner, but are supposed to avoid taking it with a very high fat meal. The FDA lists its typical side effects as possibly including nausea, dizziness, headache and dry mouth. Is there anything else I can help with? ## When exactly should I take the medication? Everything I read so far only says with a meal....but does it mean before or after the meal? I was wondering if it made a difference. Th...
Updated 9 minutes ago.
contrave and crazy dreams
2 Replies RSS
I have been having extremely vivid dreams on Contrave. Some cause me to wake up mid dream. Also noticed that I had to sleep about 20 hours on Sunday after drinking Saturday night. Anyone else seeing these side effects and should I be concerned? ## Those can be normal side effects, alcohol tends to intensify them, according to NIH reports, which is why you are usually told not to imbibe, while taking any prescription medications. It could also cause you to experience more nausea, dizziness, and diarrhea than normal. How are you feeling, now? Has there been any change? ## I seem to be adjusting. Still having vivid dreams, but not so scary that they wake me up. I've been limiting alcohol intake and I have a lot more energy. I actually feel great. No weight loss yet. Starting a new more...
Updated 3 hours ago.
Contrave and High Fat Foods
20 Replies RSS
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrave. All the warnings say is do not take with a high fat meal. Well, how long do you have to wait? There is no information on that! Has anyone heard? ## Hello, MrsMeck! How are you? Have you tried asking your doctor? Unfortunately, I'm only finding the same thing you are, not to take it with a high fat meal, but no specific time frame. Taking it with a high fat meal creates the risk of seizures. Other typical side effects, as listed by the FDA, may possibly include nausea, dizziness, headache, nervousness and anorexia. Does anyone know more? ## I spoke to a consultant at Takeda today and they recommended that I call my dr. But the problem would be that the doctor wou...
Updated 6 hours ago.
Contrave and Tramadol (horrific withdrawals)
1 Reply RSS
I took one Contrave and my regular dosage of Tramadol and wound up in the ER with such horrific withdrawals I wanted to pass out. My question is, how long after taking one Contrave before I can resume my regular Tramadol dosage? ## It can block opiates from working for you for about 3 days, or so. Was the prescribing doctor aware that you'd be taking both? Usually, according to FDA warnings, it is not safe to take a medication such as Contrave, until you are in full withdrawal from all opiate medications, or it creates the risk of your going into dangerous precipitated withdrawals. One of the ingredients in Contrave neutralizes opiates, it is often used to treat opiate overdoses, or prevent someone from abusing opiates, while being treated for addiction.
Updated 14 hours ago.
Contrave vs Belviq
67 Replies RSS
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. Then my doctor said she thought Contrave would be a better choice because it is just as effective, if not more, and cheaper...just 70 dollars a month. But, I have heart racing and feel agitated. I did not experience either with Belviq. I feel like calling my Dr. Back and asking to switch back and suck up the 200 mo. For Belviq. ## Hello, Jewels! How are you? Are you certain that Contrave is the correct name of the medication? Because it is listed by the FDA as containing Naltrexone and Buprenorphine, which is used to treat drug addiction, it is not used for weight loss. This is a narcotic analgesic, so it has the potential to be habit forming and may cause side effects,...
Updated 1 day ago.
contrave with lithium and risperidone
2 Replies RSS
Hello, I take risperidone and lithium for bi polar. My Dr. prescribed contrave for weight loss. Are these two safe to use with contrave? ## Hello, Christina! How are you? The FDA does list a warning that combining Lithium with Contrave may cause seizures, so it would likely be best to double check with your doctor, before taking it. Side effects are listed as possibly including nausea, dizziness, insomnia, and nervousness. Has anyone taken this combination? ## I take lithium and the combination of contract and lithium made me so sick and nauseous and I was only on the first week so only taking one pill
Updated 1 day ago.
wanting to quit taking contrave
99 Replies RSS
I need to know how to stop taking contrave. Can I just quit cold turkey or do I wean off? If I wean off how do I do it? ## Hello, Janice! How are you? How long have you been taking it? Why do you want to stop it? The FDA lists Contrave as being used to aid in weight loss and its typical side effects may possibly include nausea, dizziness, nervousness, insomnia and anorexia. Have you consulted your doctor? It does require slow tapering for some people. ## I was looking up how to wean myself off of Contrave and found this comment on here. I've been taking Confrave for about a month or so. I just started the 2 pills in the morning and 2 pills at night dose Sunday (today is Friday). I've felt horrible all week since increasing it. Hot flashes in my face, horrible nausea, glands some...
Updated 3 days ago.
Contrave and alcohol consumption
33 Replies RSS
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and am weary about taking in and wanting to continue to socially drink (glass of wine, socially drink on weekends) ## @pnj, According to's drug interaction checker, there ARE potentially dangerous interactions between Contrave and Alcohol. These statements go on to note the following: Consuming alcohol with Bupropion (one of the active ingredients in Contrave) may lead to an increased risk of seizures, decreased tolerance to alcohol, muscle spasms, confusion, and changes in cognitive awareness. For those reasons mentioned above, I would not encourage anyone to take the two together or even within the same day. Hope this helps! ## OK, I read the notice about alco...
Updated 3 days ago.
contrave and cymbalta
9 Replies RSS
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has anyone been on both. I actually skipped my cymbalta for last nights dose because I want off of cymbalta. I have been on 30mg since last November. Any personal experiences?? ## Hello, Erica! How are you? They can increase the toxicity of each other, as well as increasing the risk of seizures, when they are combined, according to the FDA. Thus, they should not normally be prescribed together and it is advised that this only be done as a last resort, when someone is out of other options. Is there anything else I can help with? ## I am wondering the same thing. I am also on cymbalta fornthe past month and a half and now i started contrave a week ago. Everything i read say...
Updated 3 days ago.

Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Possibly related Contrave Topics:

Contrave vs Belviq I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 67 replies
contrave and sleepiness I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 49 replies
Contrave and alcohol consumption I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 33 replies
Contrave and suboxone I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 30 replies
Contrave / ringing in ears Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 24 replies
Contrave and High Fat Foods I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 20 replies
contrave and cymbalta On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 9 replies
Contrave and appetite control I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 9 replies
Contrave and Vomiting I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 8 replies
Contrave Evening Dose I'm starting my 2nd week on Contrave tomorrow and the prescription says to take 1 in the morning and one in the even... 6 replies

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