michael langan, m.d. Says:
Oxymorphone Related To Oxycodone?
Updated
Pat Says:
I need to know if oxycodone is in any way related to oxymorphone. Does oxycodone break down in the system and then throw out oxymorphone chemicals like my doctor told me or is my urine test flawed like I believe it to be. There is no way I could have either one of these in my system yet my doctor (who really does not want to treat pain by medication only due to lack of payment by insurance company) tells me that the oxymorphone in my system is actually a chemical breakdown from the oxycodone. Comments or actual accurate knowledge anyone?
73 Replies (4 Pages)
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Oxycodone and oxycontin are broken down into predominantly nor-oxycodone and oxymorphone which is detectable in the urine. One can detect the parent compound (oxycodone or oxycontin) and the metabolites (nor-oxycodone and oxymnorphone) in the urine or just the metabolites. With that said, many of the new expanded opiate urine tests are using very low thresholds to deem a urine specimen positive and have arbitrarily lowered the GC-MS confirmation level to be commensurate with the immunoassay screening test. The usual GC-MS cutoff for opiates at the lowest level is for most opiates 300 ng/ml. However, labs such as Quest are now using an extended opiate screening test that can detect 100 ng/ml and are using GC/MS cutoff points of 100 ng/ml. Although these tests are getting more and more sensitive for drugs, the specificity is unknown. Thus they are able to detect a very small amount of oxymorphone with a high sensitivity but the specificity (or number of false positives) is unknown. There are currently no NIDA or SAMSA guidelines on cutoff values for oxycodone or oxymorphone as there is with codeine, morphine, and other narcotics and the labs are coming out with super sensitive tests without regard to how specific these tests are and can use cutoff values they establish. There needs to be an established cutoff value with which values above will be deemed positive and values below will be deemed negative. As it is, laboratories can use any value they want. With the recent news that pharmaceuticals can be found in tap water it is of paramount importance that these values be set to guide medical professionals and employers as to what constitutes a positive urine test for narcotics
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tom Says:
The same thing happen to me which was that I was taking oxycodone and the doctor made me take a drug screen and it came back positive for oxymorphone and they told me that i could not come to that clinic anymore and was wondering how that I tested positive for oxymorphone when all i was taking was oxycodone... do you think i have a case....
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woodstock 2009 Says:
WELL 2 POSSIABILITIES, 1 DRUGSTORE MADE A MISTAKE, 2 YOU MAY HAVE GOTTEN A INEFFECTIVE COMPOUND, ASK DR TO DO OBSERVATION TEST
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Justin Says:
http://www.jenniferschneider.com/articles/Conv_of_Oxycodone_7_20_7.html
This tells you whats up... 93% of people prescribed oxycodone test positive for oxymorphone.
Woodstock your a moron.. and drug stores rarely make mistakes considering everything is double and/or triple checked.
Tom - Yes you do have a case. The clinic had both wasted your time and money. Sadly I know more about the medications and their effects/side effects than my doctor that specializes is prescribing them. The doctors dealing with pain medications should be required to meet higher standards. They should know everything about the drugs they are prescribing and be updated accordingly to new information regarding the drugs. Your doctor screwed up for sure Tom.
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AJ Says:
I am taking drug tests for a child dependancy case and tested positive for oxymorphone when only using what I was prescribed which is oxycodone. Due to the facts my case manager is trying to sabotage me for a false accusation.
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Chuck Says:
It sounds like it's a common error in drug testng. I take oxycodone and a urine test came back saying Positive for morphine or oxymorphone? Not sure yet, just got the news today. Does anybody have a link or a website that I can give to the courts, lawyer's, etc as they are trying to charge me with taking a non-perscribed medication now. Thanks
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Jen Says:
Oxymorphone is Opana, and I don't see how Oxycodone could turn into Opana in your body, they are 2 completly different meds.
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Joe Says:
Jen, you shouldn't speak when you don't know what the hell you're talking about. Oxycodone will ALWAYS metabolize to oxymorphone in the body and will appear as such in urinalysis. Period. Are you even in the medical field? Tom and Pat, the doctors/screeners you folks are using are unfortunately complete f88king morons and should know better. Sad state of affairs
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Lisa Says:
My son recently had surgery and has been prescribed oxycodone. He recently did a drug test which came back postive for oxymorphone
and oxycodone...Can this happen?
A Very Worried Mother
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chell Says:
The same thing has happened to my B/F he is on probation and he got drug tested and it turned up positive for oxymorphone while taking oxycodones. he is now in jail and looking at 6 months for failing his urine test. I am sending the link to this page to his attorney and hopefully i will help his case. This is a serious problem and someone needs to do something about it!
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doogie Says:
Ok people. Even though this post is old, let me put my 2 cents in. Go to jenniferschneider.com and look for her detailed analysis on the conversion of oxycodone. It will always show up in urinalysis as oxymorphone due to oxycodone being converted in the liver. Read and all should be satisfied. Show it to your doctors.
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hunter 1 Says:
oxycodone is broken down in the liver .the after effect comes out to be oxymorphone in a drug screen
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jen Says:
Because the metabolite of oxycodone is morphone which is detected on an oxymorphone screen...I am a lab tech and deal with doctors who are clueless as to what they are looking for...its nuts!
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Striker23 Says:
If oxycodone is detected as oxymorphone my question is this - Opana is oxymorphone and Vicoden is oxycodone, can a urine test that found oxymorphone distinguish which drug, Opana or Vicoden, was detected? I'm assuming that Opana and Vicoden both would be detected as oxymorphone. Thanks.
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Ian werner Says:
Which medication works better for you if you have severe cronic Opana or Oxycodone?
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doogie Says:
Striker23-First off, vicodin is not oxycodone it is hydrocodone. Both are completely different opioids. Oxycodone is the active ingredient in percocet and oxycontin as well as a schedule 2 narcotic. Vicodin is a schedule 3 narcotic and not as strong as oxycodone. Second, oxycodone converts into oxymorphone in the liver. If you were to be urine tested, both oxycodone and oxymorphone would show up. Depending on the extent of the urine test, vicodin would either show up as hydrocodone or just an opioid. Either way, both opana(oxymorphone) and vicodin(hydrocodone) would show up seperately. Hope this helps!
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Troy Says:
Hi everyone, I have a really important question. About 3 months ago I switched pain managment Doctor's. I had been seeing the first PM Doctor for almost a year and there was never any issue with any urine test I ever took with my first pm Doctor.. I have taken a total of 3 urine tests with my new pm Doctor and as expected there was never any issue with the urine test's I was given by this new Doctor. A few day's ago I went for my Monthly Follow-Up Appt. The Doctor told me that my last urine test from the previous month had not detected any Oxymorphone in my system. He pulled out the Calloway Labs Final Report and showed me the final report. Under the "Opiates" category it stated that I was "Positive" for Oxycodone, yet negative for "Oxymorphone". The lab report also said the word 'inconsistent" next to the Oxymorphone category. How is this possible? I am precribed to take 3 10/325mg Endocet's a day for my pain issues and no other opiates.. I am hoping someone can explain this to me. Also, how long does it take to metabolize a 10/325mg Endocet pill into a typical traceable amount of Oxymorphone in ones urine? I took another urine test about 2 fay's ago and the Doctor said if the next test comeds back with the same result's, there would be "problems". All feedback and opinions are appreciated!
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Carl Says:
Oxycodone does metabolite to Oxymorphone, but not the reverse. Codeine metabolizes to about 5% Morphine, but not reverse. Vicoden and all the other names such as Norco or Lortab all are Hydrocodone and APAP in different quantities.They always have APAP in them to keep them a schedule III, Hydrocodone by it's self is a schedule II and so they don't make it by itself. It does come in Hycodan and Hycomine cough syrups, schedule III, but have over the counter, or non Federally Controlled active ingredients in it. (Hycodan is 1 tsp. = 5mg hydrocodone and 12.5mg Phenergan).unlike codeine cough syrups which is a schedule V and only because of smaller dose codeine than of a III like the pills. Hydromorphone hci is Dilaudid, 2mg,4mg,8mg and 3mg and 5mg suppository and as a cough syrup, 1 tsp = 1mg and yes, it is still a schedule II and IV injections are usually 1.5mg hydromorphone in a usual dose in the hospital and is 8 times stronger than morphine on a weight to weight basis orally and IV injection comparably. Oxycotin is time released oxycodone, such as Percocet without the APAP. Oxycontin does not come in a 160 mg tab, it did several years ago, production ceased years ago at the bequest of the FDA. Opana (oxymorphone) comes in 5 mg,10 mg, 20 mg, 30 mg, and 40 mg. The 7½ mg and 15 mg strengths of Opana ER have been discontinued as of March 1, 2011. Some resources assert that inluding the 5 and 10mg a 2, 12 and/or 15 mg IR tablets and 25, 36 and 50 mg extended release tablets will be introduced. No time frame set. The round yellow pill with a M and thought to be oxycodone with a 10 and HCI on it's bottle is 10mg oxycodone HCI. Oxycodone is a hydrocloride aka HCI which is very soluble in water. The M is for Mallincroft the generic manufacturer. Fentanyl is more than 100 times stronger than morphine, that doesn't necessarily make it better, it just comes in smaller doses obviously. It's what works for you. Some have a more drowsy effect or euphoric effect. All of these are semi-synthetic drugs from opium and morphine is a methylated from opium. I had to straighten out some answers on this an a few other threads that were related to this one, so all don't necessarily pertain to this one. Had to get the right info out there. I feel much better... now it's time for a Dilaudid :)
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Sophia Says:
Thank you to all who gave info on how the the heck oxymorphone showed up in my husband UDI test...because of testing postive for oxymorphone he has been terminated from the WHOLE health group alltogether...I mean I am jus shocked that these "Doctors" who are requesting the tests can't even research why they would find another drug, after years of tests with no problems but because of being profiled as what a "drug addict" looks like....and have the balls to insinuate my husband is taking something different than prescribed!!! My husband has lived a hard life with a disability that has pretty much caused him enormous pain everyday of his life, he has a disease called Charcot Marie Tooth, depending on the different levels of it, has disintegrated all his calve muscle and his forearms have lost severe muscle, his hands are deformed, and wears braces or he cant even walk, but because he has tattoos and is on disbility this doctor automatically smiled in his face than turned around n said "pill head"...We are so pissed off and now worried this inconclusive test will ruin his next treatment from another doctor...thank you for the Jennifer Schnieder link that was truly a God send..
We wish everyone good luck and hope it all works out but this is truly sad....
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doogie Says:
Good luck to you and your husband. If you explain the situation to your current or next pain doctor he/she should understand and at least be aware of the conversion to oxymorphone. Unfortunately some of the pain management docs out there are morons with prescription pads who assume everyone is a junkie. These same docs do not do the research in order to distinguish between lab results and possible false positives for other opiates. In relation to the oxycodone/morphone conversion, to my knowledge no other opioids will show up as anything other than their true name. Which doesn't necessarily mean they're not out there. Advice: Other than oxycodone, no other opioid is terribly beneficial taken orally. Even though some docs may want to prescribe oral dilaudid, opana ir or
morphine, they do not work as well due to low oral bioavailability. Meaning a lot of the active pain relieving medicine is wasted during ingestion. Good luck to you both.
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pretty lady Says:
Re: doogie (# 11) 
Í got dismissed from the painclinic cause Im on endocret and it didnt have oxymorphone in it why
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Jeanne Says:
I call bull on the 480 a month as a pharmacist we wouldn't even fill such a stupid script that would be 16 tabs a day.. bs
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George Says:
Years ago Numorphan was taken off the market because of pharmacy robberies. So it didn't stay too long. It's too euphoric. Oxycodone in instant release is better for pain, and does not have near the euphoric feeling. Oxymorphone is very similar too Heroin and that's the truth. Most pharmacies I know of where I live would freak out at filling one of these prescriptions.
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Seadog Says:
I am a disabled veteran and I take 150 30 mg of oxycodone a month,of course I don't get them from the V.A., in 2008 it was the first time I had ever really taken any pain meds. In my life, at that time I was 44 years old.I had a really good Dr. At the time,I started out on hydrocodine and within the first year I had gotten up to 480 15 MG of oxycodone a month, I know that sounds hi, but I needed every one of them for the type of work I do. But when the big epid3mic started and my Dr. Retired they gave me a head hunter of a Dr. And without any exams testing, or even meeting me she had cut me three hundred pills a month.To make a long story short, just this week I had every urine test I have taken for the V.A. copied for me and 2hen I went through and looked at them, every one of the test I showed positive for oxymorphone.,and a lot of the test even stated at the bottom that high doses of oxycodone condone can show a negative reading for opiates. Doesn't make sense, I hope this helped, and good luck to anyone out there that has a medical problem in this country and can't get the meds. They need just to function at work.I did get a good doctor and I am getting my oxycodone that I need. But at least I'm not trying to get full disability, and the epid3mic that this country is having with heroin I blame on the government for taking away mess. That people really.
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shugz Says:
wow , i dont come across many other with CMT. does your husband not have AFO or legs braces. walking into a doc/pharmacy with all the gear on shouldnt have someone saying "ohh hes a pill head" even thought that is the issue we face because a few (whole ton) of bad appless. i also take opana (oxymorphone) 10s as well as morphine sulfate(60s). i use to have issues all the time because i was in my 20's and i didnt have insureance at the time to pay for my braces, but after getting them i dont have any issues at pharmacies or new doctors (ive had to switch mine recently) but i wish you husband luck with the CMT
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mr wonderful Says:
Some ppl lack the enzyme tht metabolizes oxycodone into oxymorphone. Ur doc shld hv known this. I think its like 3 percent or so of the population tht lacks it.
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Jeanne Says:
The difference is it will only show as a VERY SMALL amount that is a sign that its an impurity from the opana now if it shows a signifigiant amount then you took it
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Billy Joe Bob Says:
I have been on opiates for 20 years due to failed back surgery and was prescribed oxycodone for years which seemed to build up a tolerance very quickly. I was switched to oxymorphone which is much stronger for reasons I know but won't detail. The oxymorphone has been more effective for my hands down. The ER actually does last 12 hours and it IR at 1/3 the dose is not only more effective but faster acting for me. That being said oxymorphone is much harder to get off of and the withdrawls are insanely worse than oxycodone.
Hope this helps.
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Jeannebeanie Says:
When OxyCodone breaks down it shows in a test as oxymorphone. So if your doctor doesn't know this then he shouldn't be practicing medicine...
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RachelG Says:
I would have thought the same thing if it didn't happen to me. I have never taken oxymorphone in my 35 years of life yet I tested positive for it after taxing oxycodone and ONLY oxycodone. I am blown away.
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