Oxymorphone False Positive Test

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I am prescribed 5mg of Methadone twice a day, and 5mg of oxycodone twice a day for break through pain. I have been taking my medication EVERY DAY like it's prescribed. I just received a letter from my Dr. stating that he is pulling me off of my meds because my oxycodone levels were too low and my methadone did not show up AT ALL. It also stated that I had oxymorphone in my system which I have NEVER taken. I didn't even know what it was I had to look it up. Can someone please explain to me why a medicine that I take EVERY DAY is NOT showing up in my system, and why is one that I'VE NEVER TAKEN showing up. Thank you.

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1

OXYmorphone is showing up because Oxycodone as the parent drug will not stay in your system long. Oxymorphone is the metabolite of Oxycodone. As for your urine tests not showing the proper levels??? How are they testing the level? Urine is not exact.

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2

I'm not sure how they were testing my levels but since they pulled me off of both of my pain meds cold turkey and put me through the worst withdrawals ever I guess it's kind of a moot point now.

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3

Something else I just thought of: What is your pharmacogenetic markers for opiates? You could be an ultra rapid metabolizer, rapid, normal, or slow metabolizer just because of your genetic make up. This is the new field which everyone on any drugs should have done. Find out your alleles for the CYP450 genes, and 2D6, 2C19, 3A4. 3A5, and others.

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4

How do I read the answers to these questions?

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5

This is the best explanation I can find to this issue:

practicalpainmanagement.com/treatments/pharmacological/opioids/oxycodone-oxymorphone-metabolism

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6

Monkeysmom: The time of day and your metabolism rate is going to determine the amounts of medications you will have excreted in your urine. Oxymorphone is the metabolite of Oxycodone, so that is ok it is there. That dose of Methadone is quite low, and I would question how the tests were run and CONFIRMED. Plus, have you ever had your DNA checked to see what your CytochromeP450: 2D6, 3A4, 3A5, 2C19, 2C9 metabolism enzymes are genetically? That could answer the question of why it is not there when they think it should be. You could be a ultra fast metabolizer or some other condition. These are Pharmacogenetic markers that are very important for pain management as well as psychiatric medication management.

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7

I take both prescribed drugs hydromorphone and oxycontin, nothing else period. But my urine test comes up with both of these and oxymorphone in it. Does anyone have a proven explanation for this?

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8

I always test positive for oxymorphone and can't figure out why? I take up to 100mg of oxycodone, 20/40 mg of methadone and 2mg of xanax a day. What may cause this false positive? I am very concerned. They told me to come back soon. Thank you.

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9

I'm in the military and just got hit with a failed urine test for oxymorphone. I take the prescription sertraline HCL 100mg for anxiety/ptsd. Can this cause my false positive?

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