Dangers Of Mirtazapine (Page 11)

It seems to me that Mirtazapine is a potentially dangerous drug with little information known about it. My veterinarian prescribed this drug in small quantities for my cat as an appetite stimulant, so I began reading articles on the drug and its effects. Although it is supposed to be used as an antidepressant for humans, it has a wide reputation for causing suicidal tendencies in children and young adults. It causes weight gain (the side effect my vet was looking for in my cat's case). It also can cause feelings of depression, and wooziness. I spoke with a nurse who took it and she said the effects of sluggishness and dizziness lasted 2 to 3 days. It can also cause nausea and headaches. It seems to me that these side effects are anything but what a person who is already depressed should be feeling. (suicidal tendencies that they didn't originally have, feeling tired and unwell physically, and weight gain that could cause feelings of insecurity or increased depression) Giving this drug to my cat was the worst thing I ever did. About an hour after administering it to her, she began crying, looking confused, and she could not walk straight. We figured the effects would wear off, but they seemed to worsen. The next day she was holding her head down, walking in circles (trying to walk straight) and she could not focus her eyes. We brought her to the emergency animal hospital, and they called a poison center. Even the poison center had so little information on this drug (especially being prescribed to cats) that they did not know how to counteract the effects. We believe that the drug actually caused a mild stroke in our cat, and the vet said this looked like it might be the case. On top of that, it has a 72 hour half life, so we just had to wait the drug out for her to even feel better. If this drug could cause a mild stroke in my cat, I could only imagine what it could also do to a human. With so little knowledge of the effects, and such long-lasting effects, it seems to me that it is a dangerous and harmful drug for doctors to be prescribing. A few years from now, when it actually is studied more, I bet that it will be taken off the market as another one of those trial drugs that did not work out. Until then, how many people (and animals) will it harm?

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You let a disease fester in your cat before it finally died. The vet grabbed mirtazapine as a last resort to save it from your piss poor animal care techniques. The pill didnt kill your cat. Your neglect did!

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As long as vets continue to believe that the pharmaceuticals they are doling out are safe, and don't do their own research on forums such as this, yes pets will continue to have reactions and die.

Many drugs are "approved" (whatever the hell that means) for humans but not for animals, yet they are given to animals.

My beautiful cat Gracie began getting sick in mid July. Her teeth, pancreatitis, beginning stages CRF...during one of her pancreatic flare ups, she didn't eat for a couple of days. Worrying about hepatic lipidosis, I took her to the vet. Mirtazapine was given to her ther and also prescribed. Needless to say, after that initial dose, I never gave it to her again. She immediately began eating voraciously when we got him. However, she was confused, disoriented, and meowing with a breath at the end of each meow. She is typically not a meower, so this was concerning, as well as the huge pupils. This 1/4 pill lasted a full 4 days before she returned to normal. Even the appetite stimulant part of it only lasted a cople of days but the side effects lasted longer.

I took very good care of my Gracie, and the time between mid July and August 22nd I did or know how long she would be with me. I worried about her constantly, didn't eat, had an outfit ready at night just in case something went wrong and I had to take her to emergency.

Mirtazapine and Convenia haven't had much extensive studies done, but read about them on the Internet and the stories will scare you to death.

RVT, never tell someone they neglected their pet. You don't know the situation or the person. You don't know the love they gave each other or the times they had. Comments like that really hurt people.

I treated my Gracie like a princess and the loss I am feeling now that she is gone is a pain like o other. She was my alighted for 13 years. My baby, my only child for 7 years and I loved her very much.

Something was going on inside her belly that the vets would not admit. I truly believe she experienced DIC from the anesthesia and her pancreatitis. She had pooled blood in her belly that faded a few days after dental surgery but was replaced by her literally chewing a hole in her belly. She was in pain from something going on inside her. Even with the buprenorphine (which she also didn't handle well, and is't supposed to be given to cats with kidney disease) something inside her was compelling her to gnaw a literal horror-show hole in her belly. She stopped eating 2 days before she died and her belly was extremely raw and painful. My Gracie would have suffered if I did that. It was her time, but I experienced all of those drugs. I believe they all made her unhappy, miserable, sad...

Long story but I miss her so much. I wanted to post something here when she was alive but couldn't form many thoughts amidst my worry about her.

Last note: be very cautious with your pets and Convenia, mirtazapine, and buprenorphine. Do your research before administering these drugs to your babies. Start with very small amounts.

I learned many lessons over the past 2 months. Lessons about vets, medications, intentions, love and loss.

All of you, take care and be wary. Get more than a couple of opinions. It is worth it...peace and love to all the true animal lovers out there...

Patricia

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DISCLAIMER! This writing has non-authoritative information on mirtazapine and rough assumptions on concerning this writings drug dosing scheme of mirtazapine on cats. Precise reference notes and bibliography are absent. If you give your cat mirtazapine by my calculations, which I tried to make understand _not to do!_, as it is very diffucult and very dangerous, you do so at your your own risk and liability. Your cat might get all the possible adverse effects I mentioned and more. Mirtazapine is intended for human consumption, although your vet might prescribe it to your cat, it's likely to be incorrect and extremely dangerous possibly lethal prescription. This post was made as a warning and information source to avoid any kind of mishaps of mirtazapine. I got all my references mostly from internet by search engine, wikipedia, researches and mirtazapine producers.
DISCLAIMER!

Cats brain are physiologically by basic functions very similar to humans, although obviously not alike, thus mirtazapine theoretically works for cats also. Still practically and by any other means it's not reasonable choice of drug on any animals except, maybe apes which could possibly somewhat reliably be observed on how mirtazapine is affecting them. Cats genetic survival instincts make them keep to themselves regarding most of their ails. If cat's meowing in agony, the condition of the cat is usually serious. And I'm really very sad to say that the overdose effects of mirtazapine must be one of the most scary, agonious and infernal feelings in the world not to mention what really dying to it must be. How I know this? It was prescribed for me by my doctor for superficial sleeping and I found out to be one of the very few people hypersensitive to it. So I got clear seizurish type overdose effects from mirtatzapine even from the last and smallest dose tried, 1/8 of 15 mg. My doctor recommended me to try 1/8 still after two preceding horrible trials. I got an assortment of very strong adverse effects on the first try of 7,5mg, although I really felt like I was going to die any minute, I still probably wasn't even anywhere near to death and I don't even wan't to know how awful would those feelings and effects be when one was :(. I have now read a lot about mirtazapine on internet to gather helpful knowledge. I found my way here searching about overdose information on mirtazapine and have a lot to say and something to give on this matter.

Mirtazapine a strong psyche drug for human use and it's main effects are on the psyche (most likely unnecessary treatment for cats!) and it has always occurring, but sometimes welcome side-effects causing sleepiness, lethargy and strong craving for food. It's got also lots of other side-effects, varied and unpredictable, which are very likely to remain unnoticed on pets!! The sleepiness is probably not welcome for cats, as cats already sleep the most of their day anyways. And even having the dosage corrected to right levels, mirtazapine most likely isn't the right drug for your cat or dog neither. It is not even reasonable to administer as it gets too chemistry, math and labor involved for any normal small pet owner to do, as the drug companies don't have it specially designed for small animals like cats and dogs needs. And not to mention vets clearly don't have a clue how much of it is necessary. And still even if the dosage was known for sure, mirtazapine has too many or too strong side-effects and even though all of the three main effects were desired simultaneously: *effects on brain functioning *strong drowsiness, sleepiness and lethargy *strong craving for food (your pet might still easily even be too tired to eat.). Peculiarly enough going down on under the limits of basic dose of this drug gets even more sedating the smaller the dose! Which makes it even more controversial to use just to up ones appetite. _Many_ and I mean MANY other adverse side-effects also exist with this drug of which your cat can't meow you so that you could possibly understand what's going on with this very contraindicatory medication at any time!! Not to mention the possible withdrawal and it's symptoms which are said to be one of the hardest amongst all psyche drugs.

What would be the right amount of mirtazapine for your average domestic cat? Well as we already know there for the majority of cases isn't one, for reasons I previously mentioned and for reasons that have come up on posts on this topic, but ultimately it's certainly not anywhere near 15 mg!!! Not even 1/4 or 1/8 of it!! Considering domestic cats small size (say 10 lb / 4,5 kg that is about your average well fed furry ball) vs. humans (say about 170 lb / 77,5 kg that is about average in well fed person living in welfare society). Brain size of your furry ball is only on average about 27,5 g and yours on average 1350 g.
We must take in concern the small brain size of cats when estimating the imaginary dosage for cats because mirtazapine primarily acts on the brain functions. The tricky part of estimating dosage is as the brain-body mass ratios differ a bit, but I won't get ratio effects, because of the lack of sufficient knowledge readily available about cat's anatomy to deduce ratios effects on cat's mirtazapine dosage. But it's clear that the drug dosage (mg / kg) IS NOT directly proportional to: human body weight to cat body weight -> as mirtazapine on human to mirtazapine on cat. It must be less because the binding sites for mirtazapine are filled with relatively smaller amounts of drug on cats because of relatively smaller brain size of cat. So instead we calculate the administered mirtazapine by brain weights only, although we can't be sure for know if the binding sites for mirtazapine on cat's brains are directly proportional to that of humans, or not. What comes to body size we should also consider liver and kidney sizes which should be taken in account for decomposition of the drug, so we could estimate the time cycle for each dose, but as pedantic information on cats organs was not easily available we assume here body is just a body, mainly fluids administrating system for organism needs, and acting as a "storage" for the drug as long as it's flowing in cat's system. Any calculations for decomposition (not effects) of mirtazapine will be treated here as if human body weight was directly proportional to that of cat's.
We know that basic dosage for human is 15 mg for 1350 g of brain and cats brain are on average 27,5 g which means they are about 1/50 of the size of your brain, you'd have to crush your cats mirtazapine pill to fifty pieces to get fifty doses of 0,3 mg of mirtazapine for your furry ball. It's not only impossible for normal pet owner, but it means that some vets have prescribed somewhere near 50x / 5000% doses of the basic dosage, and 17x / 1700% of the highest recommended dosage for a depressed human being (meaning that they already lack in neurotransmitter actions, which your cat probably doesn't!). Prescribing those amounts of drug to your probably neurotransmitter healthy pets is of course potentially lethal resulting in serotonin syndrome, heart failure by tachycardia and quite possibly various other body function failures: permanent organ (liver and kidney) failures and system failures, not to speak about the mental hellish effects of pets with hallucinations, extreme disorientation and anxiety-agony heart beating million until it finally stops, really it is in the worst way going crackers while dying. I really feel like crying thinking about that happening to anyones furry ball! (the reason I'm writing this information source)
Rough estimates on elimination considering body weight as the main contributor of eliminating the drug which is with cats 2,89 times faster that of humans (calculated taken into account body weight relations only), because of cat's greater body weight in relation to brain size. So if this drug was administered to a cat (DON'T DO IT!), it might be just fine to administer 0,3 mg once day to let cat _almost_ fully dispose the mirtazapine from it's system before the next dose. Given three times a day to correlate to human dosage although it would be slightly more frequent than than human 15 mg / day and build up of the drug would start to develop and also possible side-effects emerge or develop, and your cat still couldn't meow about those for you!
I believe that this preceding deducting has a lot basis for mirtazapine administration on cats, but as I have clearly stated I don't believe that cat's should be administered mirtazapine at all.

People's loved pets have died and had their share of unwanted near death experiences :( I'm truly sorry for your losses of furry friends and problems this drug mirtazapine has brought to you and your furry friends. And believe me as I say I love cats. I've had cats all my life and still do. Keep good care and love your furry friends! <3

Yours, D.P.

DISCLAIMER!
This writing has non-authoritative information on mirtazapine and rough assumptions on concerning this writings drug dosing scheme of mirtazapine on cats. Precise reference notes and bibliography are absent. If you give your cat mirtazapine by my calculations, which I tried to make understand _not to do!_, as it is very diffucult and very dangerous, you do so at your your own risk and liability. Your cat might get all the possible adverse effects I mentioned and more. Mirtazapine is intended for human consumption, although your vet might prescribe it to your cat, it's likely to be incorrect and extremely dangerous possibly lethal prescription. This post was made as a warning and information source to avoid any kind of mishaps. I got all my references mostly from internet by search engine, wikipedia, researches and mirtazapine producers.
DISCLAIMER!

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I was prescribed this for my depression. I took it for a week and was terrified at my insane rage, feeling like I wanted to kill people for looking at me wrongly. I had slight insomnia before, but after taking it, was lucky if I managed 2 hours a night. I trembled and shook, was completely spaced out and sat for hours slack jawed and drooling. I suffered terrifying blacked out moments. I stopped taking it. 48 hours in and I still shake, have heart palpitations and am slightly zombified, but feeling calmer. I have also stopped gorging on food. I ate the cupboard bare. A month's worth of snacks went in 2 days!!! I was prescribed this poison by a doctor I'd never met before, who never looked at my medical notes and never explained any of the side effects or had a discussion with me to ensure it was the correct drug for me.Never again!

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There is no need to just wait out a bad reaction to mirtazapine. Cyproheptadine (Periactin) acts as an antidote to the serotonin syndrome which causes that bad reaction. The animal (or human) will still need other supportive treatment, but cypro should speed up the recovery You can confirm this by looking at the treatment section here: ncbi.nlm.nih.gov/pubmedhealth/PMH0004531

For cats, you can get suggestions for possible dosage of cypro in this situation here: felinecrf.org/persuading_cat_to_eat.htm#mirtazapine but please consult your vet too.

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After reading all of these reports, I'm sad to report that my 15 year old cat suffered at the hands of our vet with Mirtazapine last Saturday. We had noticed she was wobbly and having trouble walking & then she stopped being interested in food and was getting quite bloated - all bad signs. We took her in for some diagnostics as she had been pretty healthy for a cat her age with the exception of a skin growth that was removed twice. (Biospy showed benign)

Our vet confirmed the signs were grave and that our cat was dying. We were beside ourselves with grief and just couldn't bring ourselves to put her down that day (it was Saturday morning and they were only open till 2pm). The vet recommended subQ fluids and an appetite stimulant (Unbeknownst to us - Mirtazapine). We thought about it for half an hour and agreed to the "treatment" as the vet seemed to suggest that doing so would help/comfort her thru the weekend so we could say goodbye.

I should preface all of this that despite her symptoms - our cat was still able to walk and hold her head up -- even jump up on her favorite box on top of a cabinet just before we left for the vet. She was definitely not "healthy" for all the symptoms described - but, still alert, cogent and moving around (albeit with wobbliness).

Well - within minutes of getting the Mirtazapine (our vet dosed her 7.5mg and she's only 5.7lbs. and highly likely dealing with liver failure for some reason) our cat became limp like a lifeless ragdoll. It was horrible. We hadn't made the connection yet (I think we thought she was just declining fast as the vet didn't seem alarmed.) and took her home. We took her outside to one of her favorite lounging spots in the yard and we noticed her paws twitching. Otherwise, her body was lifelessly limp and she couldn't hold up her head any longer. We were concerned about the twitching and her condition worsened rapidly. She started howling -- so sadly depressing like we've never heard her. We immediately called the vet & said she looked like she was suffering so much & could we come back and put her down.

The vet is only 5 minutes away and on the way - I watched her convulse and reach out with all her legs a few times. It was really terrible. She continued the curdling howling and we rushed her into the vet. As the vet gave her the IV - she seemed to be going into respiratory failure with deep pants & her tongue sticking out wildly and eyes wide open.

All of this happened before we researched this terrible drug & we're heartbroken we didn't research it first before allowing our poor 15 year old cat to suffer at the hands of this incompetent vet. Based on everything I've read - 7.5mg is OBSCENELY too much for a 15yo 5.7 lb. cat in one dose. I reached out to them today after requesting the details of her visit and asked what the rationale could possibly be for such a dosage.

In my opinion -- based on previous visits with another cat of ours - this vet is used to treating dogs and probably advised a dose appropriate for a medium-sized dog - not a little old cat!!!

I'm so angry with the vet & even angrier at ourselves. We'd accepted that she was dying, but feel horrible that we contributed to her going in this manner. It's really terrible that vets are prescribing this to elderly cats at such a high dosage -- I truly believe it gave my poor cat a heart attack or stroke -- she seemed in so much pain.

I'm posting our story here to corroborate all the other stories -- this drug is dangerous for elderly cats at such a high dosage, especially one with suspected liver problems.

It pains me to think that had we never gone to this incompetent vet, our beloved cat would've died, but with much less pain and more dignity. I know our intentions were good, but the results were so bad.

PLEASE DO NOT ALLOW YOUR VET TO PRESCRIBE THIS AT SUCH A HIGH DOSAGE. And - don't be fooled by "appetite stimulant" -- it's not a benign drug - it's a drug that affects the brain & causes what I honestly believe was a terrible stroke/heart attack.

If this post helps at least one person save their cat - it's worth it.

Feel free to ask any questions - take care!

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Dear Gigi,

My heart breaks for you as it still does for my baby who died in a very similar horrifying way due to this drug. I don't know where you live but I am in Ontario Canada and I submitted a formal complaint to the Ontario College of Veterinarians back in February of this year and it is still going through the complaints process. I felt it was my only hope of trying to bring this issue to the attention of Veterinarians. I still do not know how this will turn out but one of the points in the response of the Veterinarian who prescribed the drug was: "When searching VIN (veterinarian information network) I did not find specific discussion on side effects of mirtazapine, side effects were not listed at all or listed as rare". The literature she also included in her response states: "Mirtazapine appears to be well tolerated in both dogs and cats but use has been limited and controlled trials are lacking". Further in the report under the heading Doses: "Since no safety or efficacy trials have been performed in animals to date, currently recommended doses are based on extrapolations from human medicine and clinical experience in veterinary practice....Since the ceiling dose for cats and dogs is not currently known total daily doses of <30 mg are recommended for appetite stimulation depending upon the weight of the pet." This is UNBELIEVABLE and FRIGHTENING to me. How can it be ok for veterinarians to prescribe medication for which there is limited or no research?? I strongly encourage any pet owner who has been affected by this drug to submit a letter of complaint to their Veterinarian licencing body if for no other reason than to bring this issue to light. My next step will probably be to go to the media about this as I feel all pet owners need to be warned about this drug. It is so traumatic to watch the little baby you've loved for so many years die in such a horrifying way. There are no words to describe it. Gigi, my prayers are with you and I know you will heal. Keep all your good memories close to your heart and mind. Your baby will never be forgotten.

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Hi Simbas Mom - I recall reading your story & it broke my heart to read such a similar experience. My heart goes out to you & your beloved Simba.

There are over 200 messages here alone & many consistent with what we experienced. There's definitely some good outcomes as well -- however, they seem to be very low doses. Our vet hasn't responded to our inquiry on rationale & if we don't hear anything, our next step is to file a complaint with the veterinary board. It sounds like your complaint review is taking quite some time as ours probably will.

No matter - if our efforts results in these vets stopping such treatment - it will be worth it!

Finally - I found a recent clinical study completed by the Winn Feline Foundation on Mirtazapine. I only reviewed the abstract - but, the conclusion is the half-life is even longer in a cat with compromised health (like our cat!). You can google it - it was done in 2012 and results published this year I think?

Given that conclusion - it seems the effects would be multiplied in a cat of low weight & terminal condition.

Please keep us posted on what happens with your complaint as will I. IN our case - this vet is relatively new to the neighborhood (a main reason we started going to her) and we plan to get the word out on YELP so that other interested pet owners know the incompetence of this vet -- again, if I can do anything to help avoid such needless suffering for other pets/pet owners - I will! To that point - I'd welcome any replies to what other actions I can take in addition to the veterinary board complaint and YELP review.

Thanks - take care,
Gigi

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I am glad that I didn't ask my vet to prescribe this med for my renal cat .Reading all these comments was Very Helpful !!However A bigger problem than her appetite has occurred . She developed antibodies to Epogen. I am torn to pieces , her renal levels are now great but she just had a blood transfusion because of her severe anaemic. I don't know how long this will keep her red blood count up . All I can do is cry and try to find any help I can ..

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My cat died as a result of Mirtazapine. He had two very large seizures and several strokes. Will never use this drug ever again.

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I have a 15 yr old male Persian cat who recently vomited violently several times then diareaa, followed by not wanting to eat. After a 4 day hospital stay, he developed a UTI, gave him 1/8 tab mirtaizapine and within hours he was crying to eat. It seems to help keep up his appetite for about a week. I give it as needed, but may try every 3-4 days. Our original problem stemmed from a new kitten sold to my husband with an URI (herpes virus) and my male got very sick within 10 days after her arrival. He was treated with antibiotics which worked but he got a reoccurrence that resulted in a very expensive 4-day hospital bill followed by UTI which has become recurrent.

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My English mastiff was perscribed this and she also had a partial seizure and then after the third dose had a grand maul seizure! 2 days later (today)I had to put her down. :( I believe this drug killed my dog!

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Sorry I meant she had a partial stroke*

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My cat had a fit this morning, and that is the reason why I went on line to see whether that could be a side effect of this drug. As with Jennifer (Jan 23 '07 above) my elderly cat was given this drug, initially to increase appetite when he stopped eating 15 months ago, and more recently I was told that recent studies had shown 1/4 tablet each week could reduce vomiting.
Also, for a day or two after having each 1/4 tablet, my cat would become much more talkative. He would constantly ask for food, even though he had both dry and wet food in his bowls. The tablet is tiny, and so it is impossible to cut it accurately into quarters, so maybe this inaccurate dosage made things worse.
I will not give this to him again, and I feel very sorry for him that he had this afflicted upon him :(

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my cat with renal disease has now had 2 transfusions after developing antibodies to epogen , I plan to speak with a specialist on switching to another Med with less chance of developing antibodies . Darbepoetin renal levels r also good

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Keefe ,, my cat is actually named Keefe .. I'm also glad I didn't ask my vet for mirtazipine ! I monitor her appetite closely , but her severe anemia is the life threatening problem . I'm sure I will be doing another transfusion very soon . Please give an update on your cat .!!!! I've spent many hours researching to determine what can I do now ? The only option I've found is switching to Darbepoetin , options now are very limited from what I've been able to find out . Transfusions are another option , but are so costly I can't do many more . I can only hope I can do them long long for the antibodies to disappear before switching to Darbepoetin .. And hope antibodies don't develop again . I feel very alone in dealing with this situation because I can't find a vet with much experience with this problem , hopefully the specialist will help. I've got an appointment soon

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My cat was having trouble breathing and not eating and not walking or running. Took him to the vet. first he gave him aminophyline and cyproheptadine. then switched him to theophylline and mirtazapine. he got worse with the mirtazapine. we noticed that his breathing got worse and he didn't want to get out of his bed. we stopped it and now he's starting to run around more and now meows. why is this drug still on the market if the side effects are so bad in cats and humans? now I just have to make sure his appetite is still okay. he doesn't eat a lot in one sitting but cats are like that and he drinks water and uses litter box. so like I said I'll keep an eye on him. Might think of taking to different vet.

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Feeling so much better after reading your post. My 10 yr old border collie has just been prescribed Mirtazapine (same dose) for liver/spleen cancer. He is now on day 2 and seems to be doing better. He is much more interested in food which was my worry. I have sought advice from a homeopath too in order to to supplement his diet and the vet prescribed meds. Always worth looking at all angles and doing thorough research on all meds and their side effects. Thank you!

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I had previously worked as a police officer for just short of 3 decades, and the last 15 years of that was as an undercover narcotics investigator. I had not slept more than 4 hours in the last 20 years .
I absolutely knew something was very wrong with my body, constantly exhausted, very negative attitude, and i had bad aches and pains, its just goes on and on.
I retired and decided to sit down with a doctor and "lay it all out on the line, then let the chips fall where they may, no lies, nothing held back" I soon discovered something called a 96 hour commitment order,which i narrowly escaped by having to lie to keep from a locked down mental evaluation.
my problems are manifested from 10 years of assisting in many dead body removals while assisting ems, picking up body parts from the homeless that frequently were struck then dragged miles by trains, guns shot victims, infant death syndrome, mangled persons in auto accidents, taking of a life.....then came undercover narcotics, i thought a welcomed change, but i was living multiple personalities, depending upon the person the suspect knew me as. I wont go into the undercover part far, but it turned out much more trying than the first 10 years.
during employement some of these troubles didnt surface in me and i failed to see it in anyone else, turns out we must have been theraputical to each other, because upon retirement things surfaced in me but my police support was no longer there.
the doc. i seen after leaving police work prescribed me xanax and mirtazapine.
the xanax alone has a calming effect on me, the mirtazapine with or without the xanax makes me meaner than hell, to, well anyone. in my mind i know as im speaking i am going to make someone mad, and I JUST CANT HELP IT.
its a horrendous anger, not a pick up a club and hit you anger but a tyson type "physical bite your head off" anger and it not well controlled. good gosh I would like to be normal again

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My dog died 2 hours after taking this drug.

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