Tramadol Overdose Help

My husband passed away last February he was only 38 years old. Originally from what had happened we assumed that he had a heart attack. The other day I received the autopsy report and according to it he had a toxic level of tramadol. My question is, how many tramadol at 50mg each would he have had to of taken to be toxic? He was also on lithium and Paxil and would the interactions with the other two medicines have raised the toxicity of the tramadol without him actually overdosing? The day he passed away he was completely coherent and had no indication of slurred speech or being intoxicated. I really need help with this, I'm not understanding why this happened to him. Please help!

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Hello, LiDawn! How are you? I am very sorry for your loss.

Actually, the Paxil reduces the efficacy of the Tramadol, so that issue is eliminated, the combination would not have increased the toxicity.

As to how many tablets he would have to have taken, there is no definitive answer that I can give you, it can vary from person to person and depends on their opioid tolerance, metabolism and etc. Some people may be able to take a lot, before suffering any adverse effects, while others may experience problems after only taking a couple of tablets.

The FDA classifies this medication as a narcotic analgesic, so it has the potential to be habit forming and may cause side effects, such as nausea, dizziness, drowsiness, dry mouth and constipation.

Was he in a lot of pain? It could just be a case of him being in pain and taking too many to try to relieve it.

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the interaction of tramadol and antidepressants causes a life threatening condition called serotonin syndrome. you cannot use Paxil and tramadol together. I am very very sorry for your loss but that could very well be what happened. you can research serotonin syndrome to try to understand it. best of luck in the future. again, I'm very sorry.

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