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Dangerous Cocktail: Neurontin And Opiates

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Lionyx Says:
One of the contraindications while taking Neurontin is using opiates such as Hydrocodone (Vicodin) and Oyxcodone (Percocet). The opiates potentiate the effect of Neurotin by 14%. With Morphine, it increases the effect of Neurotin by 44%.

My husband was on Neurontin at 900 mg a day (taken in three doses). At that time, he was not taking much of his pain killer, Oxycodone (Percocet), maybe one 5mg dose a night. My husband was originally took Neurotin for shingles nerve pain.

His doctor decided to increase his dose of Neurontin to 1800 mg per day (three equal doses). Before that time, my husband increased his Oxycodone to two 5mg tablets before bedtime and another 5mg tablet about four hours later.

Upon the increase in Neurontin, my husband started to experience some adverse effects. These included:
Mental Confusion
Severe drowsiness
Lack of coordination
Numbness in toes
Swelling in feet
Mood Swings
Rapid speech, slurred speech

He could not hold a sane conversation with me, keep track of time, walk without running into things, remember what someone had just said, interact with others without hostility and being argumentative, keep awake during the daytime, and could not speak and be understood.

The symptoms escalated from minor to major in a matter of days. It necessitated medical intervention, however, due to my husband's belligerent and confused state he refused to go to the ER. He did not want to spend the money.

My husband has a mental disorder. Caution is advised in giving patients Neurotin who have mental disorders. His disorder is a personality disorder, Obsessive Compulsive Personality Disorder ( *not* Obsessive Compulsive Disorder ), which has some of the exact symptoms as Neurontin’s side effects. What transpired over two weeks, my husband’s personality disorder escalated into a monster. His behaviors were off the chart. Those symptoms from the list above are Belligerent, Hostility, Argumentative, Mood Swings, Rapid Speech.

His speech was so distorted, rapid and slurred, that the medical assistant who spoke to him on the phone was alarmed. Based on his distorted speech, the doctor decided he should go to the ER instead of seeing her.

After he essentially refused to go to the ER, my husband decided to reduce his dose of Neurontin and Percocet. Now he is going through withdrawals. I told him he should decrease it slower. However, he insists upon doing it his way, a behavior of OCPD. He went cold turkey on the Percocet, taking none now. In one day, he decreased the Neurontin from 1800mg to 900mg.

On my husband’s side is my background in nursing with a speciality in pharmacology. I started to read up on Neurotin on and the . I discovered that Neurontin’s effects are potentiated by Hydrocodone (Vicodin). Upon further reading, I found Oxycodone (Percocet) is a related to Hydrocodone and therefore would do the same thing.

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Verwon Says:
It is not actually lised as a contraindication under either medication, though you are cautioned to regularly see your doctor so your dosage can be monitored.

The problems your husband experienced could have been caused by either class or medications or the combination, it is hard to say.


Has he discussed this even with his doctor, yet?

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April Says:
via mobile
Thank you. I do not have a wife. Neither my doc nor my pharmasist made mention of this problem. My heart has been screaming that my work performance is suffering because my brain won't work right. I appreciate your plainspeak. Sorry for what you are going through.

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