Buspar (busiprone) & False Positives - Yes, They Can Happen (Page 3)

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I've noticed a-lot of poeple out there are asking about buspar, & false postives.. as well as it's relation to xanax (alprazalam). Let me start off by saying that my husband is prescribed 15mg. buspar (I believe 1 3x a day) along w/some other drugs from his pyschologist such as ambien, and depacote. I can state that I took his buspar during a horrible anxiety/panic attack (also known as busiprone) and I also need to mention I go to a methadone clinic. After taking the buspar, I went to clinic to take my usual drug-screen (also let me mention I was receiving takehomes, only going once every 2 weeks as I'd never failed a drug test), thinking nothing of it as I'd read they don't show up as anything. Well, WRONG for me.. my drug test came back 100% positive for benzo's.. I had no xanax, valium, clonpazen(sorry about the spelling there) in my system, etc. My husband also had the same problem with one of his urine drug screen's at the methadone clinic we both attend for a postive on benzo's when all he had taken was buspar & ambien, which he both has valid prescriptions for. They broke both our tests down and they came back showing up as Nordiazepam, and Oxeazepam on both -- Unfortunately our clinic is under debate about them showing up because of the way the break-down showed up. All I can say is if anyone has ever had a false-positive for buspar, please let me know. I'm trying to prove to my clinic that in come cases they can show up, maybe it has to do with certain people. I dunno? But, it happened to me and my husband both.

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41

I just tested a low positive for benzo and truthfully I do not take any drugs, only the ones prescribed. I do not take any illegals and dont even drink. I take buspare and Zoloft both so I'd say yes very true. Just get a paper from your Dr or phamacy to state this. cover all your basis.

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42

Ambien is a controlled substance. Buspar is not. If you had a positive drug screen, and these were truly the only other meds you were taking, I would guess the positive was related to the Ambien, which is a sedative.

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43

I too go to a methadone clinic and yes taking benzo's with methadone can be deadly! They will tell u that at the clinic. I messed up and took kolonopins with my methadone I totaled my truck and was in the hospital on life support for almost two weeks could not breath on my own or have no memory of any of it until I came to and began to breath on my own it almost killed me so please stop taking them with the methadone!!!!

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44

Jmike I am very familiar with the terrible things that can happen with mixing benzos and methadone. I also understand the horrible fears related to anxiety and panic attacks. It realy is all about how much a person takes of each. She isn't on a very high dose so taking one or two zanax when she needs to is ok. I'm on 46mg of methadone and I never take more then two at the most. So just being aware of the amounts she takes and being smart about it and taking them properly is ok. But they will build up in your system if someone is taking large amounts constantly and that is unsafe as well and obviously if you take them too much you build a tolerance to them and they don't work as well. I know when your stressin out or freaking out cuz you feel like your gonna die you need that relief or as I call it that ahhhh factor fast! Your wife is lucky to have a caring husband and I hope I helped.

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45

CLEARLY TOOK WAYYYY TOOK MUCH! DAM! Gotta be smart bout that s*** and only take them if you need them. Def only take one or two at the most. If your on a high dose... like 70mg of methadone or more then you def shouldn't be taking xanax. But if you must then id take only one of the lowest dose. Everyone is different and some people have beat on their bodies and systems a lot worse then others so you really need to be cautious and smart about the s***. I mean no one wants to end up on the living room floor unresponsive, with foam and vomit running down your face... while your family watches medics try UNSUCCESSFULLY to revive you.... Then have to cover you with blanket and leave you there on the living room floor for hours because the County Coroner isn't gonna rush to pick up a dead junkie!......True story... happened to my neighbor in may. That's why I stress being smart and taking them cuz you need them....cuz some people really do need them but they don't need a handful or everyday. I mean if your having panic attacks daily then you need some more in depth treatment than pills!

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46

I also go to methadone clinic and iio am on buspar , flexiril, bupap(barbituate) and adderall and estrogen....I just changed to new clinic today and I tested positive for benzos and opioid today!!!! I have been clean for along time and do not use anymore i have not used in along time (years) they use a cheap dip stick test and both me and another take home patient tested positive today and haven't taking anything accept proscribed medication. They are sending off for a verification. I am very upset because I have never had this happen and Dr said buspar isn't a benzo but nurse and director said it does come up benzo on dip stick but sdoesnt on confirmation....so what is going on???? If I would have used I wouldn't even worry but I don't use and I have my take homes on the line for something I haven't done!!!!!

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47

My boyfriend and I go to the methadone clinic. He drops dirty for benzos. He takes ambien. I take busbar and now all of a sudden I'm dropping dirty for benzos. The first two months it was coming back negative for everything. Sometimes I wonder about those drug tests. I have been clean since September 1st.

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48

My boyfriend and I go to the methadone clinic. He drops dirty for benzos. I take busbar and now I am dropping dirty for benzos. The first 3 months I have been droppING clean and all of the sudden I'm dirty for benzos. Sometimes I wonder about those drug tests.

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49

My clinic Discovery House in pgh pa actually told me to show them my script cause that could happen. Have them call and ask other clinics. Just a suggestion to you. Hope all works out for u.

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50

I just tested positive yesterday after starting buscar for the first time last week. and I been tested lately 3 times a week for the past 3 months clear with my other meds.
So YES, it DOES test a positive on benzos

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51

Hello I am having the same problem, I am on Probation and took a UA and it showed I had Benzos in my system, I am also on Busirone to

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52

I just looked this up because I take buspirine 10 mg and took a drug test for a job & they said I was positive for methadone. And now they have to send it off to work all this out. Makes me just wanna go to the dr to get taken off!! Seriously! But I kno I don't do anything but what prescribe to me and that'll everything will be fine. Hope everything works out for you!

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53

I have been an RN for 25 years and can tell you that Buspar is not chemically or pharmacologically similar to benzodiazepines in ANY way. If any of you have had a "false positive" it's not from Buspar. Secondly, some of you said you're on probation. Taking any medication from a person when it's not prescribed to you is against the law. The lack of common sense on this forum astounds me. I came here because my son is being prescribed this medication and he was concerned it would show up on his drug screen at MEPS for the military. It won't as, I've shown him.

DESCRIPTION:

"BuSpar (buspirone hydrochloride) is an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.

Buspirone hydrochloride is a white crystalline, water soluble compound with a molecular weight of 422.0. Chemically, buspirone hydrochloride is 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl) butyl)-8-azaspiro [4,5] decane-7,9- dione monohydrochloride. The empirical formula is C21H31N5O2·HCl.

BuSpar is supplied for oral administration in 5 mg and 10 mg, white, ovoid-rectangular, scored tablets. BuSpar tablets, 5 mg and 10 mg, contain the following inactive ingredients: colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate."

CLINICAL PHARMACOLOGY:

"The mechanism of action of buspirone is unknown. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models.

Buspirone has moderate affinity for brain D2-dopamine receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.

Buspirone HCl is rapidly absorbed in man and undergoes extensive first pass metabolism. In a radiolabeled study, unchanged buspirone in the plasma accounted for only about 1% of the radioactivity in the plasma. Following oral administration, plasma concentrations of unchanged buspirone are very low and variable between subjects. Peak plasma levels of 1 to 6 ng/ml have been observed 40 to 90 minutes after single oral doses of 20 mg. The single-dose bioavailability of unchanged buspirone when taken as a tablet is on the average about 90% of an equivalent dose of solution, but there is large variability.

The effects of food upon the bioavailability of buspirone HCl have been studied in eight subjects. They were given a 20-mg dose with and without food; the area under the plasma concentration-time curve (AUC) and peak plasma concentration (Cmax) of unchanged buspirone increased by 84% and 116% respectively, but the total amount of buspirone immunoreactive material did not change. This suggests that food may decrease the extent of presystemic clearance of buspirone, but the clinical significance of these findings is unknown.

A multiple-dose study conducted in 15 subjects suggests that buspirone has nonlinear pharmacokinetics. Thus, dose increases and repeated dosing may lead to somewhat higher blood levels of unchanged buspirone than would be predicted from results of single-dose studies.

In man, approximately 95% of buspirone is plasma protein bound, but other highly bound drugs, e.g., phenytoin, propranolol, and warfarin are not displaced by buspirone from plasma protein in vitro . However, in vitro binding studies show that buspirone does displace digoxin.

Buspirone is metabolized primarily by oxidation producing several hydroxylated derivatives and a pharmacologically active metabolite, 1-pyrimidinylpiperazine (1-PP). In animal models predictive of anxiolytic potential, 1-PP has about one quarter of the activity of buspirone, but is present in up to 20-fold greater amounts. However, this is probably not important in humans: blood samples from humans chronically exposed to buspirone HCl do not exhibit high levels of 1-PP: mean values are approximately 3 ng/ml and the highest human blood level recorded among 108 chronically dosed patients was 17 ng/ml, less than 1/200th of 1-PP levels found in animals given large doses of buspirone without signs of toxicity."

Ref: dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6fac36b4-b223-479e-913f-f8c9cdb9e119

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54

Yeah I just had a false positive today from my first drug test I've been out of jail for for days and I've been taking busbars for 3 months and it showed up as a benzo but my parole officer is aware of this and did not violate me

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55

I've been on methadone and my opinion get off immediately yes it helps for hard core users. But its an awful detox nearly killed me

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56

I take a weekly drug test and I take bupar mine came back as benzo when I have been clean for a year I was so frustrated over it

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57

Hello i just wanted to reply to u about bupar well i am to on the methadone program n my urine tested false positive for valum n i do not take valum or tenazaapam n that was in my urine to im really upset because im tryn to figure it out to well best of luck for u n your husband i also take zolof for depression n that to will test positive so the clinic faxed the urine screen to see wats hoing on i am not going to say i took something that i didnt. Good luck

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58

I'm taking buspirone cuz I have savers anxiety but I'm also on Cps will I get my kids back cuz I hope so cuz there my life

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59

I'm taking buspirone cuz I have savere anxiety but I'm also on Cps will I get my kids back cuz I hope so cuz there my life

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60

I take Methadone and oxycodone & also Buspar...had a urine test done at the pain clinic a few months ago...have never had a dirty urine of any kind in the 4+ yrs I've been going there...my test came back negative for the Methadone...sent me for blood work, evidently came back the way it should...they never questioned me after that...

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